DIAGNOSIS OF VITAMIN B12 DEFICIENCY IN CHILDREN BY USING METHYLMALONIC ACID, HOMOCYSTEINE AND HOLOTRANSCOBALAMINE
نویسندگان
چکیده
Objective: Vitamin B12 deficiency is a common health issue in children. Though the sensivity of serum vitamin measurement for diagnosis low, combined methylmalonic acid, homocysteine and holotranscobalamin have been reported to be more specific biomarkers early accurate diagnosis. In this study, we aimed verify children by measuring homocysteine, determine accuracy them.
 
 Material Methods: The study included 277 patients aged
منابع مشابه
Cobalamin (vitamin B12) deficiency detection by urinary methylmalonic acid quantitation.
A study was made to assess the value of cobalamin deficiency detection through quantitation of urinary methylmalonic acid (MMA). Urinary MMA was measured in 1118 patients suffering from megaloblastic anemia, other anemias, elevated red cell mean corpuscular volume, or unexplained neurologic disorders. Patients without proven cobalamin deficiency had urinary MMA levels less than 20 micrograms/ml...
متن کاملIn vitamin B12 deficiency, higher serum folate is associated with increased homocysteine and methylmalonic acid concentrations.
To the Editor: In the December 11, 2007, issue of PNAS, Selhub et al. (1) suggest that the association between elevated serum folate and methylmalonic acid (MMA) concentrations in vitamin B12 deficiency resulted from disruption of MMA metabolism by folate. An alternative explanation is that the increase in both serum folate and MMA concentrations resulted from the severity of the vitamin B12 de...
متن کاملThe limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency.
Treatment of B12 deficiency is important to prevent progressive neurological and/or hematologic disease but requires a secure diagnosis. The aim of this study was to evaluate second line tests of B12 status as prognostic indicators of a hematologic response to vitamin B12 therapy. Forty-nine patients referred with low, serum vitamin B12 concentrations were treated with intramuscular B12 and re-...
متن کاملAccumulation of methylmalonic acid caused by vitamin B12-deficiency disrupts normal cellular metabolism in rat liver.
To clarify the relationship between intracellular concentrations of methylmalonic acid and metabolic and growth inhibition in vitamin B12-deficient rats, hepatic methylmalonic acid levels were assayed and inhibition of glucose and glutamic acid metabolism by methylmalonic acid was studied in isolated hepatocytes. Vitamin B12-deficient rats (14 weeks old) excreted more urinary methylmalonic acid...
متن کاملIn vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations.
In a recent study of older participants (age >/=60 years) in the 1999-2002 National Health and Nutrition Examination Survey (NHANES), we showed that a combination of high serum folate and low vitamin B(12) status was associated with higher prevalence of cognitive impairment and anemia than other combinations of vitamin B(12) and folate status. In the present study, we sought to determine the jo...
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ژورنال
عنوان ژورنال: K?r?kkale Üniversitesi T?p Fakültesi Dergisi
سال: 2023
ISSN: ['1302-3314', '2148-9645']
DOI: https://doi.org/10.24938/kutfd.1263790